Abstract
(1) The vascular permeability factor is present in the renal cortex.This factor has no pressor activity and is quite different from renin. (2) The vascular permeability factor has the characteristics of a protein. Immunoelectrophoretic study reveals a single precipitation line. (3) Administration of the vascular permeability factor to mice causes cerebral hemorrhage. (4) Rabbits subjected to renal ischemia develop cerebral hemorrhages but are provided protection against it through lanolin feeding. (5) Some evidence is presented indicating that the renal vascular permeability factor plays an important role in the development of vascular lesions.
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