Abstract
The quasi-equilibrium assumption is often used to simplify the analysis of reaction diffusion problems, including those that arise in drug dissolution and ionization processes. This approximation often makes the governing equations tractable, and analytical solutions may then be obtained. However, the application of the quasi-equilibrium assumption may lead to simplified solutions that (1) are apparently inconsistent with stated boundary conditions and (2) have a physical interpretation that is different from those of the original problem statement. Herein we discuss these two issues as they arise in the modeling of drug dissolution processes. In spite of the different conceptualizations, the concentration profiles and dissolution fluxes obtained from the full and approximate solutions converge as the reaction response times exceed those of diffusion, thus supporting the applicability of the quasi-equilibrium assumption for ionized drug dissolution processes.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
