Abstract
AbstractThe high anti‐tuberculosis activity of pyridine‐4‐carboxylic acid hydrazide (isonicotinic acid hydrazide, INH), together with the chemical similarity of pyridine and thiazole, has induced us to synthesize the thiazole carboxylic acid hydrazides and to investigate their possible effects upon Mycobact. tuberculosis.The chemical structure/biological activity relationship is extensively discussed.In agreement with the hypothesis, thiazole‐2‐carboxylic acid hydrazide in in vitro and in in vivo tests proved to be of equal tuberculostatic activity to pyridine‐2‐carboxylic acid hydrazide (picolinic acid hydrazide); they almost completely inhibited the development of experimental tuberculosis in mice.
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