Abstract
Already in ancient medical literature there are indications of the beneficial influence of infectious diseases on the course of psychoses. In 1879, Rosenblum (Odessa) was the first to inoculate the mentally ill with relapsing typhus and in 22 cases had 11 cures and 3 improvements (the remaining 8 cases were unchanged). In 1917, Wagner Juregg began inoculating malaria in progressive paralysis. Repeated observations of schizophrenics who recovered clinically under the influence of accidental infection (sore throat, typhus) led Wiesel and Markuszewicz to test malaria vaccination in 46 schizophrenics, of whom 27 had already completed observations.
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