On the Transplantation of Rous' Fowl Sarcoma No. I into Gunea-Fowls and Turkeys

Abstract

The transplantation of mammalian tumours into heterologous but nearly-related animals has, as is well known, often been attended by partial success, though permanent growth in an indefinite number of subsequent generations has not been attained. Woglom (1913, 1929) has reviewed very fully the whole literature on the subject, and his two publications, as well as the review by Uhlenhuth and Seiffert (1925), should be read by anyone interested in the subject. Murphy9s experiments with the Jensen rat sarcoma and other mammalian tumours, grown successfully for several generations in chick embryos, while they could not be grown in new-born or adult chickens, brought out clearly the importance of the presence or absence of a defensive mechanism on the part of the host. Since 1907 (Rywosch) it has been known that embryos are unable to produce hemolysins and bacteriolysins to any considerable extent. This accounts apparently for the results of Murphy9s grafting experiments. On the other hand, Murphy found that the growth of mammalian tumour cells in subsequent generations of chick embryos did not alter their morphological appearance nor their biological characters. They remained mammalian tumour cells and when implanted into animals of the original mammalian species they showed as rapid a growth as if they had not been grown for some time in a chick embryo.