Abstract
The term holobiont was first introduced by Mindell (Biosystems 27:53–62, 1992) to describe a host and its primary symbiont; the definition was subsequently expanded to the host plus all of its symbiotic microorganisms, including viruses (Rohwer et al., Mar. Ecol. Prog. Ser. 243:1–10, 2002). The hologenome is defined as the sum of the genetic information of the host and its symbiotic microorganisms (Zilber-Rosenberg and Rosenberg, FEMS Microbiol Rev 32:723–735).
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