Abstract
The studied conditions of supercritical fluid chiral chromatography of salbutamol and salbutamol sulfate allowed to assumethe possibility of ionic interactions in the process of separation of enantiomers. It is shown that the structure of the hydrocarbon radical of 1- (4-hydroxy-3- (hydroxymethyl) phenyl) -2-aminoethanol associated with the chiral fragment, and, consequently, the physicochemical characteristics of the substance molecule, such as the number of hydrogen donors and acceptors polar surface, significantly affect the ability to communicate with the sorbent selectors under conditions of supercritical fluid chromatography
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have