Abstract
Several years ago I proposed a model (Fig. 1) for the structural organization of the transcriptional unit in eukaryotic cells (Georgiev, 1969) based on studies of the structure of nuclear DNA-like RNA (dRNA), the precursor of mRNA (pre-mRNA) (reviewed in Georgiev, 1972). According to this model, the structural gene(s) is(are) localized at the end of the transcriptional unit, or transcripton. The main part of the transcripton, between the promoter and structural gene(s), does not carry structural information but contains acceptor sites that interact with structural and regulatory proteins of chromatin. Some of the acceptor sites are reiterated and may be present in different transcriptons, allowing one regulatory factor to simultaneously switch on or off many transcriptons. Newly formed giant pre-mRNA is a transcript from the whole transcripton. It consists of an informative part at the 3’-end and a noninformative part. The latter is degraded while the former, corresponding to a true mRNA, is transferred to the cytoplasm.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
