Abstract
The structures of Tamerit® (A) and Galavit® (B) pharmaceutical preparations have been solved by X-Ray single crystal and powder diffraction. These are luminol sodium salts possessing immunomodulatory and anti-inflammatory properties. It is shown that Tamerit® (A) is a hydrated salt, while Galavit® (B) is a mixture of two polymorphic modifications (B1 and B2) of anhydrous salt. Compound A is crystallized in a monoclinic system: a = 8.3429(4) A, b = 22.0562(11) A, c = 5.2825(2) A, β = 99.893(3)°, V = 957.59(8) A3, and Z = 4; sp. gr. P21/c. Compound B1 is crystallized in a monoclinic system: a = 14.7157(18), b = 3.7029(19), c = 16.0233(15) A, β = 116.682(13)°, V = 780.1(4) A3, and Z = 4; sp. gr. P21/c. Compound B2 is crystallized in an orthorhombic system: a = 27.7765(15) A, b = 3.3980(19) A, c = 8.1692(19) A, V = 771.0(5) A3, and Z = 4; sp. gr. Pna21. The absence of phase transitions between the B1 and B2 polymorphs has been established by differential scanning calorimetry.
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