Abstract

AbstractCompared with many chemotherapy and radiotherapy modalities, selective killing of cancer cells is a pivotal feature of cold atmospheric plasma (CAP). Understanding its underlying mechanism will build the foundation of CAP‐based cancer treatment. Additionally, we provided forward‐looking thinking to extend the definition of selectivity from conventional cases involving a single‐cell line to a coculture case. Finally, the newly established physically based treatment strategy provides unprecedented visions to realize selectivity beyond the previously established concepts based on reactive species and direct killing effect.

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