Abstract
To the Editor: Cardiac memory (CM) has been investigated extensively over the last decades.1–3⇓⇓ Whereas early studies focused on electrotonus as a central determinant of cardiac memory,3 more recent work has considered changes in ion channels driven by to-be-determined transcriptional events.4,5⇓ However, any transcriptional mechanisms involved remained largely unidentified. In the September 5 issue of the journal, we reported our first study investigating transcriptional mechanisms of CM.6 Based on previously shown parallels between CM and memory in the CNS,7 which incorporates the cAMP response element binding protein (CREB) as an important transcription factor,8 we investigated the role of CREB in …
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