Abstract
SummaryDuring interphase, prior to the first post-irradiation mitosis, the preservation of a percentage of cells with chromosomal aberrations (bridges, acentric fragments) takes place in the rat liver and in the corneal epithelium of the mouse.Cells of corneal epithelium with such aberrations die in F1-F3 or F1.The dose-dependence relationship of the percentage of corneal cells with aberrations was obtained. Circa 100 per cent of cells had lethal chromosomal rearrangements after being exposed to 2–3 kr of x-rays. Mitotic activity recovered, but only in part, even after x-irradiation with 10–30 kr.The formation of giant polyploid cells from irradiated diploid ones was demonstrated.It was calculated that the percentage of cells without bridge and acentric fragments increased two times and the mitotic index 1·5 times after exposure in CO-atmosphere as compared with irradiation in air. The differences of the mitotic index and the percentage of cells with aberrations in mouse corneal epithelium were used as a model for these estimations. Hypothermia (21°) during irradiation had no protective effect on the rate of mitotic activity recovery and on the percentage of cells with aberrations.
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