Abstract
Meiotic recombination plays a critical role in achieving accurate chromosome segregation and increasing genetic diversity. Many studies, mostly in yeast, have provided important insights into the coordination and interplay between the proteins involved in the homologous recombination pathway, especially the recombinase RAD51 and the meiosis-specific DMC1. Here we summarize the current progresses on the function of both recombinases and the CX3 complex encoded by AtRAD51 paralogs, in the plant model species Arabidopsis thaliana. Similarities and differences respect to the function of these proteins in other organisms are also indicated.
Highlights
More than 10 years ago the Arabidopsis nuclear genome DNA sequence was published (Arabidopsis Genome Initiative, 2000)
The present review analyzes the current knowledge about the process of meiotic homologous recombination (HR) in Arabidopsis, and is mainly focused on the role of AtRAD51 and AtDMC1 and the CX3 complex, which is encoded by AtRAD51 paralogs
RAD51, DMC1, AND DNA STRAND EXCHANGE Once generated by Spo11, resection of the double-strand breaks (DSBs) proceeds in a 5 -3 direction, resulting in 3 single-stranded tails that are required for the following step in the meiotic HR process
Summary
More than 10 years ago the Arabidopsis nuclear genome DNA sequence was published (Arabidopsis Genome Initiative, 2000). In meiosis HR is a critical process required to repair the DNA double-strand breaks (DSBs) produced at prophase I. RAD51, DMC1, AND DNA STRAND EXCHANGE Once generated by Spo11, resection of the DSB proceeds in a 5 -3 direction, resulting in 3 single-stranded tails that are required for the following step in the meiotic HR process.
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