On the Relationship Between Spatial and Temporary Dose Distribution in Radiotherapy Optimization

Abstract

The method of mathematical modeling was used to conduct studies aimed at establishing the dependence of optimal dose-fractionation regimens on the spatial dose distribution in tissue and on the tumor location with respect to the spatial dose distribution. The TDF model was used to describe the response of normal tissue to radiation, and the multi-target model was used to describe the reaction of the tumor to radiation. It was shown for the first time that a change in the tumor location relative to the existing spatial dose distribution, as well as a change in the nature of its spatial distribution, led to a change in the parameters of the optimal dose fractionation regimen.