ON THE RELATION BETWEEN THE VARIETY OF MICRO-ORGANISMS AND THE COMPOSITION OF STONE IN CALCULOUS PYELONEPHRITIS.

Abstract

No subject in renal diseases has been more discussed than calculus, especially as regards the etiologic factors involved in the production of the stone. Many theories have been held regarding the origin of stone in nephrolithiasis, but of these most have been finally abandoned from insufficient evidence; thus the idea that telluric conditions play an important role in this connection has been practically abandoned by all, as also the belief that gout was the most important etiologic factor in the development of such a condition, while Senator, Von Noorden and numerous other observers have definitely shown that the method of living and the variety of diet play, speaking generally, but a small part. Our ideas regarding the formation of uric acid in the body have undergone a marked change, through the work of Horbaczewski and Kossel, who showed that in a large number of cases, at least, the uric acid