On the relation between the function of the liver and urolithiasis. Effect of 1-phenyl-propanol on experimental urolithiasis

Abstract

The auther carried out a series of animal experiments to study effect of 1-phenyl-Propanol on the formation of Conteben Calculi and the Nephrocalcinosis due to administration of parathormon.Changes of the liver function have also been examined simultaneously.The results are summarized as follows:1) The formation of Conteben calculi is noticed in 78.6% of the mice by oral administration of Conteben 15mg daily for eight days.On the other hand, 52.5% of mice developed Conteben calculosis by combined dosage of 2% 1-Phenyl-Propanol and Conteben; and 50.0% mice by 5% 1-Phenyl-Propanol and Conteben.2) The main factor of 1-Phenyl-Propanol to prohibit formation of Conteben calculi is to increase the protecting of the urinary colloids and the detoxicating function.3) 1-Phenyl-Propanol also prohibits development of Nephrocalcinosis in case of hypercalcemia in rats by administration of parathormone.It is because that 1-Phenyl-Propanol works to preserve liver function.4) The PAS positive substance is seen in the calcified area of the kidney which has the formation of Conteben calculi or the Nephrocalcinosis due to administration of parathormone.It is thought that a close correlation will exist between development of calcium deposition and changes of the renal tubular epithelium.5) In case of hypercalcemia in rats by administration of parathormone an impairment of liver is suspected in the histological findings.6) A close correlation is suspected between hepatic change and degree of calcification of the kidney.7) There is no noticeable side reaction to the liver and kidney by use of 1-Phenyl-Propanol. The same is confirmed by histological studies.