Abstract
The accumulation of the stable RNA species, ribosomal RNA (rRNA) and transfer RNA (tRNA), in bacteria is regulated in accordance with the physiological state of the cell. (This subject is extensively reviewed in refs. 1–4.) Thus at high growth rates ribosomal RNA is accumulated rapidly, the synthesis of ribosomal RNA accounting for up to 40% of the instantaneous rate of RNA synthesis (5,6), although the cistrons coding for these RNA species comprise less than 0.5% of the bacterial genome (7,8). However, at low growth rates, when, for example, the carbon source is restricted, the accumulation of rRNA may proceed at less than 20% of the rate approached during maximal exponential growth. This type of regulation occurring during balanced growth of the bacterium may be regarded as a “fine tuning” (9).
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