On the regional distribution of cerebral microvascular 'raspberries' and their association with cerebral atherosclerosis and acute circulatory failure.

Abstract

In this follow-up study, cerebral microvascular formations termed 'raspberries' were quantified according to cerebral atherosclerosis (C-ASCL) and acute circulatory failure (ACF). We also examined the regional distribution of raspberries throughout the brain. The study population consisted of adult individuals who had undergone a diagnostic neuropathological autopsy. Groups were formed to examine the association between raspberries, C-ASCL and ACF (control group, C-ASCL group, C-ASCL+ACF group [n=47 per group] and a combined C-ASCL-tot group [n=94]). To examine the regional distribution, additional groups were formed based on previously known raspberry densities of the frontal cortex (high-, medium- and low-density group [n=6 per group]). Raspberries were quantified on scanned haematoxylin-eosin-stained sections. Cortical raspberry density did not differ at a statistically significant level between the control group, the C-ASCL group and the C-ASCL+ACF group (P=0.10) but did so between the control group and the C-ASCL-tot group (P=0.033). The total raspberry density of the high-, medium- and low-density groups differed at a statistically significant level (P=0.005), which remained in group-to-group comparisons of the high- and medium-density groups (P=0.015) and the high- and low-density groups (P=0.002). Raspberries were rare in cerebral white matter and in the cerebellum. An association between raspberry density and C-ASCL is supported but is weaker than previously indicated. An association with ACF is not indicated. The raspberry density of the frontal cortex provides an approximation of the brain's total raspberry density.