On the Question of the Norm of some Laboratory Indicators of Homeostasis in People over 60

Abstract

Currently, there are no reference values for many laboratory indicators of homeostasis for gerontological patients, which complicates the objective interpretation of their disorders.Aim of study. Based on a comparison of the reference values of some laboratory indicators of homeostasis of volunteers over 65 and people of working age, we offer their conditional norm for people of gerontological age.Materials and methods. Studies of laboratory indicators of homeostasis were carried out in 25 volunteers aged 60 to 85 years. The comparison group consisted of 50 donors aged 18–59 years. Investigated indicators: lipid peroxidation and antioxidant blood system; factors of endogenous vascular regulation; apoptosis of peripheral blood lymphocytes; blood rheology; endotoxemia, immunology. Statistical analysis of the data was performed using the Statistica 10 software package (StatSoft, Inc., USA); when comparing the indicators, the nonparametric Mann–Whitney U test (abnormal distribution) was used.Results. In elderly and senile people, due to physiological aging, as well as the influence of endogenous and exogenous factors and concomitant diseases, there are significant differences in the reference values of some laboratory parameters from the parameters of the same name for people of working age.