On the potential for evolutionary change in meristematic cell lineages through intraorganismal selection

Abstract

Abstract In the absence of sexual recombination somatic mutations represent the only source of genetic variation in clonally propagating plants. We analyse the probability of such somatic mutations in the shoot apical meristem being fixed in descendant generations of meristems. A model of meristem cell dynamics is presented for the unstratified shoot apical meristem. The fate of one mutant initial is studied for a two- and three-celled shoot apical meristem. The main parameters of the model are the number of apical initials, the time between selection cycles, number of selection cycles and cell viability of the mutant genotype. As the number of mitotic divisions per selection cycle and number of selection cycles increases the chimeric state dissipates and the probability of mutation fixation approaches an asymptote. The value of this fixation asymptote depends primarily on cell viability, while the time to reach it is mainly influenced by the total number of mitotic divisions as well as the number of initials. In contrast to the presumed operation of Muller’s Ratchet in plants the chimeric state may represent an opportunity for deleterious mutations to be eliminated through intraorganismal selection or random drift. We conclude that intraorganismal selection not only can be a substantial force for the elimination of deleterious mutations, but also can have the potential to confer an evolutionary change through a meristematic cell lineage alone.