On the Pituitary Adrenal System in the Rats with the Administration of Acetoacetate

Abstract

Acetoacetate was administered to the rats fed with either the standard diet or the high-protein high-fat diet during eight weeks. Acetoacetate influences on the anterior pituitary lobe and the adrenal glands including the adrenal medulla and causes hyperfunction in the animals especially fed with the high-protein high-fat diet. It is suggested that the anterior pituitary and adrenal system plays an important role in the progress of the disordered carbohydrate metabolism induced by the administration of acetoacetate and that it might cause a steroid diabetes.