Abstract
The oxidation of α-oxobutyrate in rat kidney and liver mitochondria depleted of endogenous ATP has been studied. The use of malonate and atractyloside as inhibitors made it possible to identify the compartmentation of the successive steps in the mitochondrial structure. It is suggested that oxidative decarboxylation of α-oxobutyrate occurs only inside the atractyloside-sensitive barrier ( i.e. the inner membrane), while the carboxylation step i.e. the carboxylation of propionyl-CoA to methylmalonyl-CoA may occur either inside or outside this barrier.
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