Abstract
1. 1. The effects of ferramidochloromycin (FACM) on a sensitive strain of Bacillus subtilis was examined. 2. 2. Ferrioxamine B failed to antagonize the antimicrobial effects of FACM. The antibiotic exerted no effect on the synthesis of lipids, RNA and DNA whereas it arrested protein synthesis through inhibiting lysyl tRNA synthetase and hence preventing the incorporation of [ 14C]lysine. 3. 3. Treatment of B. subtilis with relatively high concentrations of FACM and for long incubation periods converted the cells from rod to cocci shape with the accumulation of N-acetyl aminosugars. The effect is presumably a secondary one.
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