Abstract
[8- 14C]adenine was administered to pregnant mice in order to incorporate isotope into DNA and RNA of dividing fetal tissue (brain and liver) that subsequently becomes mitotically inactive in the adult animal. The radioactivity in the DNA and RNA purines of these and other tissues from the offspring were determined at periods from nine days to one year after birth. During this period there was no loss of 14C from the DNA purines of brain and liver, whereas the RNA of these tissues did lose radioactivity. These results further confirm the metabolic stability of DNA and indicate that radioactive atoms incorporated into DNA of the liver and brain of embryos may remain fixed for the life of the animal.
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