Abstract
Major differences were found between the effectiveness of various goitrogens in reducing compensatory ovarian hypertrophy. These differences are not related to the hypersecretion of thyrotropin produced by these drugs, but appear to be due to peripheral toxicity effects. Methimazole exerts by far the greatest inhibitory effect upon ovarian hypertrophy. Methimazole toxicity is expressed mainly in the hypometabolic rat. Concomitant thyroid feeding reverses the effects of both methimazoJe and propylthiouracil upon adrenal, thyroid and Ovary. In athyreotic rats methimazole caused ovarian involution below the level found in the thyroidectomized rat. In rats in which rostralafferents to the medial basal hypothalamus had been surgically interrupted there was no correlation between the effects of this “deafferentation” upon compensatory ovarian enlargement and on goiter formation. A competition between thyrotropin and follicle-stimulating hormone for some common hypothalamic factor thus seems unlikely. The result...
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