Abstract
Laser ablation of phthalocyanine nanoparticles has potential for cancer treatment. The ablation is accompanied by the formation of microbubbles and the sublimation of nanoparticles. This was investigated in a liquid medium simulating tissue using optical-acoustic and spectral-luminescent methods. The thresholds for the appearance of microbubbles have been determined as a function of nanoparticle size. For the minimal size particles (80 nm) this threshold is equal to about 20–25 mJ cm−2 and for the maximal size particles (230 nm) this threshold is equal to about 7 mJ cm−2. It was estimated that the particle temperature at which bubbles arise is near 145 °С.
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