Abstract
The effect of external Na on both the neuronal efflux and uptake of 3H-(-)noradrenaline (NA) was investigated in isolated vasa deferentia obtained from reserpine-pretreated rats. Na impaired efflux and activated uptake both in a concentration-dependent manner. The two effects of Na followed Michaelis-Menten kinetics when Tris was used to maintain the osmolarity of the medium, but showed non-hyperbolic kinetics (with the Lineweaver-Burk plot being parabolic) when Li was used to replace Na. Cocaine was a potent non-competitive inhibitor of efflux.
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