Abstract
Publisher Summary Cholesteryl esters represent the bulk of the lipids deposited in the aorta during atherosclerosis and an unusual increase in blood cholesterol levels and specific changes in the serum lipoprotein patterns can be directly correlated with the prevalence of coronary artery diseases and of heart attack. Such a causal relationship between elevated plasma cholesterol levels and incidence of atherosclerosis has led to extensive search for effective and safe hypolipidemic agents, and the major efforts of biochemists, clinicians, and pharmacologists have centered on various dietary manipulations and specific drugs. Available information on the hypocholesterolemic effects of polyunsaturated lipids is reviewed; rapidly accumulating evidence suggests that large amounts of cholesterol are eliminated through the bile and feces in animals given polyunsaturated lipids. Because polyunsaturated lipid intake improves the solubility of cholesterol in the bile micelles, such treatments should prevent gallstone formation.
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