Abstract
The 32P-labeled DNA cleavage experiments showed that the biological activity of the bleomycin(BLM)-Fe(III)OH − complex is evidently induced by addition of H 2O 2 and KO 2, or by irradiation of UV light. Hydrogen peroxide contributes to the conversion from the inactive BLM-Fe(III)OH − complex to the active BLM-Fe(III)O 2H − complex, and UV light to the reduction of the BLM-Fe(III)OH − complex to the BLM-Fe(II) complex. The proposed hypothetical mechanism for cyclic function of BLM-iron complex is similar to that of certain heme-oxygenases and heme-oxidases.
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