Abstract
As previously described, a falsely positive or non-specific complement fixation reaction can be produced with certain tuberculo-antigens; the mechanism of the reaction is described in the present article. Examination of the antigen in the non-specific reaction shows that it can assume the same complement fixing power, cohesiveness and oil-wettability as antigen sensitized by immune serum. This indicates that fixation of complement is not a specific immune reaction, but only a secondary effect due to the surface properties of suitably modified antigens.
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