Abstract
The effects of amphetamine were studied on the spontaneous motor activity and other behaviour in aggregated mice using a modified jiggle cage. Amphetamine alone (2.5, 7.5 and 10 mg/kg) produced a fairly dose-dependent increase in spontaneous motor activity, excitatory behaviours and mortality. The effects were almost totally abolished after pretreatment with α-methyl tyrosine (α-MT) but could be restored temporarily by l-DOPA-treatment preceding amphetamine. Multiple-dose pretreatments with reserpine and α-methyl-meta-tyrosine (α-MMT), singly or in combination, somewhat reduced but did not abolish the effects of amphetamine (at 8 hr) and invariably augmented these at longer intervals (16 hr), especially after combined pretreatments. Adrenergic blockers were used to block these augmented amphetamine effects. Chlorpromazine totally suppressed all amphetamine effects, whereas phenoxybenzamine blocked the hyperexcitability, aggressiveness and mortality but not the spontaneous motor activity-effects significantly. These results are discussed with relevance to the possible roles of noradrenaline and dopamine in mediating amphetamine-induced behaviour as observed in these experiments designed for depletion, repletion and blockade of endogenous catecholamines.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
