On the Mechanism of Action and Metabolic Control of the Multifunctional Enzyme Complex that Catalyzes Adenylylation and Deadenylylation of Escherichia coli Glutamine Synthetase

E. R. Stadtman,A. Segal,W. A. Anderson,J. H. Mangum,B. Hennig,A. Ginsburg,M. Brown

doi:10.1007/978-3-642-80698-8_16

On the Mechanism of Action and Metabolic Control of the Multifunctional Enzyme Complex that Catalyzes Adenylylation and Deadenylylation of Escherichia coli Glutamine Synthetase

E. R. Stadtman, A. Segal + Show 5 more

https://doi.org/10.1007/978-3-642-80698-8_16

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Publication Date: Jan 1, 1972

Affiliation: National Heart Lung and Blood Institute, Lung Institute, National Institutes of Health

#End Products Of Glutamine Metabolism #Deadenylylation Of Glutamine Synthetase + Show 8 more

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Abstract

Glutamine metabolism in E. coli is modulated by enzyme catalyzed adenylylation and deadenylylation of glutamine synthetase (GS) in response to fluctuations in the intracellular concentration of glutamine, α-ketoglutarate and various nucleoside tri phosphates. Adenylylation is accompanied by a decrease in catalytic activity (1,2), a change in divalent ion specificity (1), a change in sensitivity to cumulative feedback inhibition by 9 different end products of glutamine metabolism (3,4) and a substantial shift in pH optimum (3).

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