Abstract
Calf skin tropocollagen has been investigated by a variety of techniques: light scattering, velocity and equilibrium sedimentation, viscometry, flow birefringence, optical rotation, and electron microscopy. Some discrepancies among molecular weights and lengths obtained by other workers from various measurements and preparations are confirmed. From a critical assessment of the data, it is concluded that the molecular weight is at most about 310,000. The best estimate of the length of the rod-like macromolecule appears to be 2800 Å although values from electron microscopy are about 15% smaller.
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