Abstract
The toxic polypeptides α-, β-, γ- and δ-dendrotoxin (DTX), known to be potent blockers of voltage-dependent potassium channels of the Kv1 family, were purified from the venom of the green mamba Dendroaspis angusticeps. Their binding behaviour to synaptosomal membranes of rat brain was analysed and compared with that of kaliotoxin (KTX), in a competition assay using [ 125I] KTX. α-DTX and δ-DTX were found to compete with radioiodinated-KTX (IC 50 of 8 pM and 0.2 nM respectively), whereas γ-DTX did not. Several minor components that competed with radioiodinated-KTX binding were identified and characterised chemically and biologically.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
