Abstract
Three recent single-cell papers use novel CRISPR-Cas9-sgRNA genome editing methods to shed light on the zebrafish cell lineage tree.
Highlights
Three recent single-cell papers use novel CRISPR-Cas9sgRNA genome editing methods to shed light on the zebrafish cell lineage tree
Naturally occurring somatic mutations induced during normal cell division carry enough information to specify with high precision the organismal cell lineage trees of complex organisms, such as mouse and possibly even human [1]
In accordance with the multiple discovery theory, the idea is presented in three independent, almost simultaneous, publications, all applying it to the discovery of the zebrafish cell lineage tree [3,4,5]
Summary
Three recent single-cell papers use novel CRISPR-Cas9sgRNA genome editing methods to shed light on the zebrafish cell lineage tree. Science has yet to know the cell lineage tree of a more complex model organism. Naturally occurring somatic mutations induced during normal cell division carry enough information to specify with high precision the organismal cell lineage trees of complex organisms, such as mouse and possibly even human [1].
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