Abstract
Avian anterior (ALD) and posterior (PLD) latissimus dorsi muscle homogenates were tested for autolysis of proteins at pH values for which muscle proteases have been described (pH 4.0, 7.0, and 8.5). The action of MgCl 2 and CaCl 2 at physiological concentrations on these autolytic activities was measured to determine if changes in ion concentration could initiate proteolysis. At pH 7.0, it was found that alterations in CaCl 2 concentrations within physiological limits in the presence of a MgCl 2 concentration below physiological levels could activate or inhibit autolysis. Changes in magnesium concentration also could activate autolysis. This calcium effect was greatest for the PLD muscle. The possible role of calcium compartmental changes in initiation of contractile protein breakdown following denervation is discussed.
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