Abstract
Rabies is a viral zoonotic infectious disease that affects mammals and is caused by genotypes/species of the Lyssavirus genus (Rhabdoviridae, Mononegavirales), with the genotype 1 (classic rabies virus - RABV) being the most prevalent. Despite continuous efforts, rabies is still an incurable disease that causes thousands of deaths amongst humans worldwide. Due to a wide range of hosts and the different evolutionary paths of RABV in each host, several host-specific variants have arisen in an ongoing process. The result of RABV replication in nervous tissues may lead to two opposite clinical outcomes, i.e., paralytic/dumb form and encephalitic/furious one. The paralytic form creates dead-end hosts mainly amongst herbivores, while the furious form of the disease allows for augmented transmission when manifested in gregarious carnivores, as their natural aggressive behavior is accentuated by the disease itself. The aim of this article is to propose a theoretical model intended to explore how the rabies virus intrinsically modulates the immune system of different host classes, the pathological changes that the virus causes in these animals and how these elements favor its own perpetuation in nature, thus providing a basis for better prediction of the patterns this disease may present.
Highlights
Few transmissible diseases have been so perennially feared and historically documented as rabies
The aim of this article is to propose a theoretical model intended to explore how the rabies virus intrinsically modulates the immune system of different host classes, the pathological changes that the virus causes in these animals and how these elements favor its own perpetuation in nature, providing a basis for better prediction of the patterns this disease may present
This article aims to propose a theoretical model to explore: how the rabies virus intrinsically modulates the immune system of different host classes; pathological changes that the virus provokes in these animals; and how such alterations favor its own perpetuation in nature under a host-parasite coevolutionary point of view, based on previously published data in each of these fields and their extrapolations
Summary
Few transmissible diseases have been so perennially feared and historically documented as rabies. This article aims to propose a theoretical model to explore: how the rabies virus intrinsically modulates the immune system of different host classes; pathological changes that the virus provokes in these animals; and how such alterations favor its own perpetuation in nature under a host-parasite coevolutionary point of view, based on previously published data in each of these fields and their extrapolations. It is not the objective of this article to provide an exhaustive review on rabies
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More From: Journal of Venomous Animals and Toxins including Tropical Diseases
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