Abstract
<h2>Abstract</h2> The mechanism underlying the effect of dextran on the lysis of plasma clots was studied. With the aid of <sup>125</sup>I-plasminogen, the formation of radiolabelled derivatives of urokinase-induced plasminogen activation was followed in clotted plasma. The activation was enhanced by the presence of dextran, but the rate of formation of the complex between plasmin and α<sub>2</sub>-antiplasmin was not. By measuring the amount of plasmin activity remaining after addition of plasmin and α<sub>2</sub>-antiplasmin to clots or fibrinogen solutions, it was found that in purified fibrin clots the α<sub>2</sub>-antiplasmin activity was impaired in the presence of dextran. In fibrinogen solutions dextran appeared to have no effect on the α<sub>2</sub>-antiplasmin activity. It is concluded that two different mechanisms are involved in the dextran-induced improvement of plasma clot lysis - an increased plasminogen activation rate and decreased α<sub>2</sub>-antiplasmin activity. The latter effect is apparently dependent on the morphologically different type of fibrin formed in the presence of dextran.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.