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Abstract
Intraperitoneal inoculation of the receptor‐destroying enzyme neuraminidase had little effect on spleen amyloid development in mice during caseination. However, incubation of normal syngeneic lymph node cells with neuraminidase before they were injected into mice during casein treatment significantly enhanced the amyloid‐promoting effect of the cells. It is suggested that neuraminidase‐treated lymph node cells may be preferentially trapped in the spleen with subsequent transfer of an amyloid component to macrophages. The polycation DEAE‐dextran, known to accelerate amyloid formation if given intraperitoneally with casein, did not influence the effect of cell transfer. This may indicate that the amyloid promoting mechanisms of the two membrane‐active substances are different.
Published Version
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Schedule a callMore From: Acta pathologica et microbiologica Scandinavica. Section A, Pathology
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