Abstract
Abstract Eucalyptol increases the microsomal activity of rat liver after a single dose given subcutaneously. Further doses do not enhance the effect. Eucalyptol does not affect the concentration of cytochrome P450 in liver microsomes. In this it differs from pheno- barbitone. Both drugs increase the biliary flow but only pheno- barbitone enhances the excretion of conjugated bilirubin after an intravenous load of bilirubin. The results suggest that the induction of liver microsomal enzymes elicited by eucalyptol differs from that elicited by phenobarbitone.
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