Abstract
Abstract: Some experimental conditions in connection with the ovalbumin‐stimulated release of histamine from the actively sensitized guinea‐pig lung in vitro and the influence of isoprenaline on this release have been studied. At 37° the release process was completed within 15 minutes. Incubation did not change the tissue content of histamine extractable by boiling. Isoprenaline, 2×10‐8 M, inhibited 50–60 per cent of the control release of histamine. The effect was fully blocked by propranolol, 10‐7 M. The inhibitory effect of isoprenaline was found to be restricted to the calcium‐dependent release of histamine. The preincubation time of isoprenaline was not critical. An increase in the dose of antigen did not impair the ability of isoprenaline to inhibit the release of histamine.
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