On the hyperglycemic factor in urine of psychoses.

Abstract

SUMMARY The urine of schizophrenics, epileptics, and depressives contains hyperglycemic facor which causes a raise of the blood glucose level of rabbits. Compared with the schizophrenic cases with prospect for brighter prognosis or much tended to recovery, those tending into psychic deterioration excrete factor much stronger in effect, cases with brighter prognosis may, however, excrete factor of stronger effect at the aggravation period, whereas they excrete, at the recovery period, stronger factor until the factor goes fully extinguished. Concerning epileptics, one among five cases, gave rather stronger hyperglycemic factor, while the same from the remaining cases lied within the range obtained from normal cases. Concerning depressive cases, there was one case with brain damage excreting much stronger hyperglyacemic factor, while the remaining gave values ranging within any normal. As the summary of the biochemical data: in accordance to Mayer‐Gross method, urine of schizophrenics were adjusted to pH 4.5 with CH3COOH, absorbed by kaolin, dissolved in NH4OH, and precipitated with acetone. With this starting material kept dry at room temperature, its hyperglycemic activity decreased by 1/2 one year later and by 1/5–1/6 by two years later. The starting material was fractionated by means of the acid precipitation and the fractions went treated with ethanol and sodium sulfate. The final product was able to raise the blood glucose level of rabbit to that extent of 1.14 mg% per 1 mg. The final product is considered to belong to mucoprotein.