Abstract
Evolution All known living organisms belong to one of three broad domains: archea, bacteria, and eukaryotes. But could there be life on Earth so different that it defines a novel fourth domain? In a Perspective, Woyke and Rubin explain that scientists may have missed signs of such unusual organisms. Powerful genomic technologies overcome the limitations of earlier searches and allow scientists to characterize microbes that cannot be grown in the laboratory. With these advanced tools, we may now be poised to discover fourth-domain organisms—if they exist. Science , this issue p. [698][1] [1]: /lookup/doi/10.1126/science.1258871
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