Abstract
AbstractOvaries from rabbits one to three months old were examined to demonstrate the histogenesis of ovarian interstitial cells.Electron micrographs showed that “primary interstitial gland cells” with abundant agranular endoplasmic reticulum were present prior to appearance of follicular atresia and that extensive development of the agranular endoplasmic reticulum and accumulation of lipid droplets occurred in the epithelial cells of medullary cords and granulosal cell nests. Therefore, it was concluded that the “primary interstitial gland” of juvenile rabbit ovaries is of epithelial origin, derived from the medullary cords and the granulosal nests, although the “secondary interstitial gland” is considered to arise from the theca interna of atretic follicles.This conclusion was confirmed by biochemical and histochemical demonstration of 3β‐hydroxysteroid dehydrogenase, an enzyme system necessary for steroid biosynthesis. The activity of 3β‐hydroxysteroid dehydrogenase increased significantly at two months when the agranular reticulum began to devlop in epithelial cells. Histochemical findings showed that the cells having the enzyme activity were consistent with the cells containing a large quantity of lipid.
Published Version
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