Abstract
AbstractNew estrone‐lactam esters, 17α‐aza‐D‐homo‐Δ1,3,5(10)‐estratrien‐3‐ol‐17‐one‐N,N‐bis(2‐chloroethyl)‐aminocinnamic isomers and p‐N,N‐bis(2‐chloroethyl)aminophenylbutyrate have been synthesized and tested in P388 leukemia in vivo and P388 and L1210 leukemias in vitro. The effect of these compounds on SCE rates and on cell kinetics in cultured human lymphocytes was studied also.
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