Abstract
The detection of elevated levels of p53 protein is a common finding in many different human tumour types [1, 2]. Elevated levels of the protein can be found in some tumours as an early event in the neoplastic progression and often seem to be associated with the transition to malignancy [3, 4]. Several large recent surveys suggest that in several tumour types high levels of p53 may be associated with a poor prognosis [5, 6, 7, 8]. Since these results imply that high levels of p53 may be of clinical importance it is of great interest to understand the mechanisms that underlie the expression of this potential tumour marker protein and its biological consequences. In this review, the sometimes controversial evidence for the different mechanisms that underlie the accumulation of p53 will be discussed and some unifying concepts proposed.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
