Abstract
Six rheumatoid sera were selected for studying the possible presence of rheumatoid factors belongings to all three major immunoglobulin classes. Indirect evidence by immunoelectrophoresis for IgA rheumatoid factors is presented for all six sera. A more detailed examination established the presence of IgA rheimatoid factors in some preparations. Indirect evidence for the existence of IgA rheumatoid factor in saliva is also presented. The IgA rheumatoid factors appear to be reactive in the latex fixation test as well as in tests utilizing rabbit and human incomplete Rh antibody. These rheumatoid factors appear to resemble other IgA antibodies in their molecular weight and sensitivity characteristics. IgG rheumatoid factors were demonstrated by isolation of the IgG fraction in two sera. The IgG rheumatoid factors were demonstrable by latex fixation test but not the other two tests used in this study.
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