Abstract
A tentative hypothesis is presented to account for the dissociation of the effects of various centrally-acting drugs and other agents on performance of the Continuous Performance Test (C.P.T.) and the Digit Symbol Substitution Test (D.S.S.T.): L.S.D., secobarbital, pentobarbital meprobamate and phenobarbital produced significantly greater impairment of the D.S.S.T. than of the C.P.T., while chlorpromazine, sleep deprivation and centrencephalic epilepsy had the reverse effect. Psychological, neurophysiological, electroencephalographic and neuropharmacological data were cited which suggested that the tests were affected differently because they are dependent upon the functioning of somewhat different neural organizations which are, in turn, differentially sensitive to the action of various centrally-active agents.
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