Abstract
The lipoproteins of normal and pathological human sera were obtained by preparative ultracentrifugation, and their flotation patterns were determined by analytical ultracentrifugation runs. A computer program for the differential flotation distribution function is given. The low density and the high density lipoprotein fractions could be regarded as homogeneous, and also in pathological states they showed negligible variation in particle size (Hyperlipoproteinemia type II and V). The distribution functions of these components were not altered by a lipid-lowering therapy. The very low density lipoproteins and the chylomicrons ( s f > 44 S f) showed a broad continuum which indicates a wide-spread heterogeneity in particle size.
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