On the detectability of different forms of interaction in regression models

Abstract

We consider the ability to detect interaction structure from data in a regression context. We derive an asymptotic power function for a likelihood-based test for interaction in a regression model, with possibly misspecified alternative distribution. This allows a general investigation of different types of interactions which are poorly or well detected via data. Principally we contrast pairwise-interaction models with ‘diffuse interaction models’ as introduced in Gustafson et al. (Stat Med 24:2089–2104, 2005).